Opportunity Information: Apply for W81XWH 19 SCIRP TRA
The Department of Defense Spinal Cord Injury Research Program (SCIRP) Translational Research Award (TRA) is a discretionary funding opportunity administered by the Department of Defense, Department of the Army, through USAMRAA. Its central purpose is to fund translational spinal cord injury (SCI) research that can push promising scientific and clinical observations toward real-world clinical use. In practical terms, the program is looking for projects that do more than generate basic knowledge; it wants studies designed to speed up the development, validation, and eventual clinical introduction of therapies, medical devices, or healthcare practices that could improve outcomes for people living with SCI.
The opportunity frames translational research as work that bridges and actively connects basic science and clinical application. It highlights that strong translational proposals can originate from many starting points, including laboratory discoveries, population-based or epidemiologic findings, and clinicians observations drawn from patient care and anecdotal evidence. A key emphasis is that applicants should not treat translation as a simple one-way pipeline from bench to bedside. Instead, the DoD encourages a two-way, iterative approach where insights from clinical experience inform laboratory work, and laboratory findings loop back to shape clinical studies, product development decisions, and practical care strategies. This back-and-forth flow is presented as an important feature of competitive research plans under this mechanism.
In terms of the types of projects that fit, the announcement provides illustrative examples rather than an exhaustive list. It explicitly mentions demonstration studies of pharmaceuticals and medical devices in preclinical systems, as well as clinical research on therapeutics, devices, or practice approaches that leverage human tissues or other human-based resources. The underlying theme across these examples is readiness and trajectory: the work should be positioned to move an observation closer to a clinical application, whether that means generating the preclinical evidence needed to justify human testing, refining a device or therapeutic strategy with clinically relevant models, or performing clinical investigations that can directly inform patient care, product development, or practice guidelines.
The announcement also points applicants to established translational development frameworks, specifically referencing a report of the National Cancer Institute Translational Research Working Group (linked in the notice). Applicants are strongly encouraged to use these developmental pathways when designing their studies and writing their applications. The intent is to ensure projects are mapped to a coherent translation plan with clear steps, decision points, and evidence milestones that support progression toward clinical utility.
Administratively, the opportunity number is W81XWH 19 SCIRP TRA, and it supports awards via grant and cooperative agreement mechanisms. It is categorized under Science and Technology and other Research and Development, with CFDA number 12.420. Eligibility is listed as unrestricted, meaning it is open to any type of entity unless further limits are described elsewhere in the full announcement. The posting indicates an expected three awards. The listing shows an award ceiling of 0, which typically signals that the maximum amount is not specified in that field and would need to be confirmed in the full funding announcement or program guidance. The opportunity was created on April 15, 2019, with an original closing date of August 27, 2019.Apply for W81XWH 19 SCIRP TRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Spinal Cord Injury, Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Apr 15, 2019.
- Applicants must submit their applications by Aug 27, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Spinal Cord Injury Research Program (SCIRP) Translational Research Award (TRA)
What is this funding opportunity?
The SCIRP Translational Research Award (TRA) is a discretionary funding opportunity from the Department of Defense (DoD), administered by the Department of Defense, Department of the Army, through USAMRAA. It supports translational spinal cord injury (SCI) research intended to move promising observations toward real-world clinical use.
What is the main goal of the SCIRP Translational Research Award?
The central goal is to fund translational SCI research that accelerates development, validation, and eventual clinical introduction of therapies, medical devices, or healthcare practices that could improve outcomes for people living with SCI. The program emphasizes projects designed to push beyond basic knowledge generation and toward clinical utility.
What does "translational research" mean in this announcement?
In this opportunity, translational research is described as work that bridges and actively connects basic science and clinical application. It is positioned as research that helps convert scientific or clinical observations into practical clinical tools, interventions, or practices.
Does the DoD view translation as a one-way "bench to bedside" pipeline?
No. The announcement explicitly discourages treating translation as a simple one-direction pipeline. Instead, it encourages a two-way, iterative approach where clinical insights inform laboratory work, and laboratory findings feed back into clinical studies, product development decisions, and practical care strategies.
What kinds of starting points can lead to a strong translational proposal?
The opportunity states that competitive translational proposals may originate from multiple starting points, including laboratory discoveries, population-based or epidemiologic findings, and clinician observations drawn from patient care and anecdotal evidence.
What types of projects does the TRA support?
The announcement provides illustrative examples (not an exhaustive list). Examples include demonstration studies of pharmaceuticals and medical devices in preclinical systems, and clinical research on therapeutics, devices, or practice approaches that leverage human tissues or other human-based resources. Across these examples, the common expectation is that the work is positioned to move an observation closer to clinical application.
Are the examples of supported projects a complete list of what is allowed?
No. The notice describes the examples as illustrative rather than exhaustive, meaning other project types may fit if they align with the program's translational purpose and trajectory toward clinical use.
What is the underlying theme the program is looking for across proposed studies?
The underlying theme is readiness and trajectory toward clinical application. Projects should be designed to move an observation closer to practical use, such as generating preclinical evidence to justify human testing, refining a device or therapeutic strategy with clinically relevant models, or conducting clinical investigations that directly inform patient care, product development, or practice guidelines.
Does the opportunity support preclinical work?
Yes. The announcement explicitly mentions demonstration studies of pharmaceuticals and medical devices in preclinical systems as an example of the kinds of translational efforts that may be supported.
Does the opportunity support clinical research?
Yes. It explicitly mentions clinical research on therapeutics, devices, or practice approaches, including studies that leverage human tissues or other human-based resources.
What is meant by "human-based resources" in the examples provided?
Based on the wording in the announcement, "human-based resources" includes human tissues and other resources derived from or involving humans. The notice presents these as an example context for clinical research under this mechanism.
Is there guidance on how to structure a translational development plan?
Yes. The opportunity references established translational development frameworks and specifically points applicants to a report of the National Cancer Institute Translational Research Working Group (linked in the notice). Applicants are strongly encouraged to use these developmental pathways when designing their studies and preparing their applications.
Why does the announcement reference the National Cancer Institute Translational Research Working Group framework?
The stated intent is to help ensure projects are mapped to a coherent translation plan with clear steps, decision points, and evidence milestones that support progression toward clinical utility.
What is the opportunity number for this award?
The opportunity number listed is W81XWH 19 SCIRP TRA.
Who administers this program?
It is administered by the Department of Defense, Department of the Army, through USAMRAA.
What award mechanisms are used for this opportunity?
The listing indicates awards may be made via grant and cooperative agreement mechanisms.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 12.420.
How is the opportunity categorized?
The opportunity is categorized under Science and Technology and other Research and Development.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is open to any type of entity unless further limits are described elsewhere in the full announcement.
How many awards are expected?
The posting indicates an expectation of three awards.
Is there a maximum award amount (award ceiling) listed?
The listing shows an award ceiling of 0. This typically indicates that the maximum amount is not specified in that field and would need to be confirmed in the full funding announcement or program guidance.
When was this opportunity created?
The opportunity was created on April 15, 2019.
What was the original closing date for this opportunity?
The original closing date listed is August 27, 2019.
What should applicants keep in mind about the "two-way" translation emphasis?
The notice emphasizes an iterative, back-and-forth approach where clinical experience can shape laboratory experiments, and laboratory results can in turn guide clinical study design, product development decisions, and practical care strategies. This iterative flow is presented as an important feature of competitive research plans under the TRA mechanism.
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