Opportunity Information: Apply for RFA IP 21 002
This CDC cooperative agreement (RFA IP 21 002; CFDA 93.185) funds the creation of a coordinated US surveillance network focused on measuring how often children get sick from major enteric and respiratory viruses, how those illnesses progress over time, and how well vaccines prevent related medical visits and hospitalizations. The network is designed to produce consistent, comparable data across multiple institutions by developing and using standardized research protocols and shared case definitions, enrollment methods, and laboratory testing approaches. In practical terms, the program supports prospective, active surveillance rather than passive reporting, meaning participating sites are expected to systematically identify and enroll eligible pediatric patients as they present for care, rather than relying on incomplete routine reporting.
The illnesses of interest span three main areas. First is acute gastroenteritis (AGE), with a focus on norovirus, rotavirus, and other enteric viruses. Second is acute respiratory illness (ARI) caused by a wide range of respiratory viruses, explicitly including influenza, respiratory syncytial virus (RSV), parainfluenza viruses, human metapneumovirus, rhinoviruses, enteroviruses (including EV-D68), adenoviruses, and coronaviruses such as SARS-CoV-2. Third, the network also monitors serious pediatric syndromes that may be linked to viral infections, specifically acute flaccid myelitis (AFM) and multisystem inflammatory syndrome in children (MIS-C). By capturing both common viral syndromes (AGE and ARI) and rarer but high-impact conditions (AFM and MIS-C), the program aims to provide a fuller picture of pediatric viral disease burden in real-world healthcare settings.
Participating institutions are expected to find and enroll children who seek healthcare or diagnostic testing for acute illness across inpatient units, outpatient clinics, and emergency departments. Sites enroll patients who meet standard symptom-based eligibility criteria and then confirm viral infections using approved molecular assays, which helps ensure that case classification is accurate and comparable across the network. This lab-confirmation requirement is a key feature because it moves estimates beyond symptom-only diagnoses and enables virus-specific burden estimates, coinfection analyses, and more reliable comparisons across seasons, regions, and age groups.
A central deliverable of the network is vaccine effectiveness (VE) estimation in pediatric populations. The NOFO calls for accurate VE estimates for influenza, rotavirus, and COVID-19 vaccines, and it anticipates evaluating additional vaccines that could become available during the project period, such as RSV and norovirus vaccines. In effect, the network is set up to rapidly generate evidence on how well vaccines prevent medically attended illness (including emergency visits and hospitalizations), with the flexibility to add new vaccine products or target pathogens as the immunization landscape changes.
The data produced by this effort are intended for direct public health and clinical use. Burden estimates, VE findings, and natural history information are expected to inform best practices for diagnosis and treatment, shape or refine vaccine recommendations, and evaluate the real-world public health impact of vaccination and prevention programs. Because the surveillance is anchored in healthcare encounters, the outputs are especially relevant for understanding and reducing virus-related medical visits and hospital use among children, including identifying which viruses are driving the most severe outcomes and which age groups are most affected.
Administratively, this opportunity is run by the US Department of Health and Human Services through the CDC (ERA). It is a discretionary funding opportunity using the cooperative agreement mechanism, indicating substantial federal involvement in coordinating or guiding the work across awardees. Eligibility is broad and includes various levels of government, public and state-controlled institutions of higher education, tribal governments and organizations, public housing authorities/Indian housing authorities, and nonprofit organizations with or without 501(c)(3) status (with additional eligibility details referenced in the full announcement). The NOFO was created on November 17, 2020, with an original application deadline of February 8, 2021 (applications due by 5:00 p.m. ET). The maximum award amount listed is $1,950,000, and CDC anticipated making about 7 awards, aligning with the goal of building a multi-site national network capable of producing robust, generalizable pediatric estimates.Apply for RFA IP 21 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "US Enhanced Surveillance Network to Assess Burden, Natural History, and Effectiveness of Vaccines to Prevent Enteric and Respiratory Viruses in Children" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Nov 17, 2020.
- Applicants must submit their applications by Feb 08, 2021 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,950,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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