Opportunity Information: Apply for PAR 21 039
The Stephen I. Katz Early Stage Investigator Research Project Grant is an NIH R01 funding opportunity (PAR-21-039) designed specifically for early stage investigators who want to launch a bold, genuinely new research direction. The core idea is to give an ESI room to pursue an innovative concept before they have the kind of pilot results that normally anchor an R01. Because of that goal, the FOA explicitly prohibits preliminary data in the application. In practice, this means the proposal needs to be compelling on the strength of the question, the conceptual framework, the rigor of the experimental design, and the investigator's ability to carry it out, rather than on previously collected supporting results.
Scientifically, this announcement targets basic experimental studies that involve humans and that meet the NIH definition of a clinical trial while still being considered basic research. The emphasis is on prospective studies in which human participants are assigned to different conditions and the researcher manipulates an independent variable to observe biomedical or behavioral outcomes. The intent is fundamental understanding: studies should be aimed at uncovering basic mechanisms or principles of human biology, behavior, or related phenomena, without being primarily driven by the near-term development or testing of a specific product, intervention, or applied process. If the work is instead oriented toward a specific application, such as product development or a clearly translational objective, NIH expects applicants to use a different FOA that is more appropriate to applied clinical trials (either "clinical trial required" or "clinical trial not allowed," depending on the circumstances).
Programmatically, proposed projects must align with the scientific missions and interests of one or more participating NIH Institutes and Centers. That means applicants should pay close attention to NIH institute priorities and fit, since alignment with an IC's mission is a basic expectation for responsiveness. Although the opportunity is framed as an R01, its distinguishing feature is the Stephen I. Katz mechanism's focus on enabling a high-risk pivot or fresh trajectory for ESIs, particularly where preliminary data do not yet exist and are not permitted to be included.
Eligibility is broad across U.S.-based organizations and includes many common applicant types: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; tribal organizations that are not federally recognized; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses) and small businesses; and other eligible entities. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, non-U.S. institutions are not eligible to apply as applicant organizations, and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components may be included when allowable under NIH policy, consistent with the NIH Grants Policy Statement definition of a foreign component.
Administratively, the sponsoring agency is the National Institutes of Health, the instrument is a grant, and the activity category spans areas such as education, environment, health, income security, and social services as reflected in the listing. The opportunity was created on November 9, 2020, and the original closing date listed is December 28, 2023. The source information does not specify an award ceiling or the expected number of awards in the provided fields, so those details would typically need to be confirmed directly in the full FOA text or related NIH materials.
Overall, this FOA is best understood as an NIH pathway for ESIs to propose rigorous, prospective, experimentally controlled human research that is fundamentally mechanistic and discovery-oriented, while removing the usual expectation of preliminary data. It is intentionally structured to support a research reset or strategic shift early in a career, provided the work fits NIH institute missions and is framed as basic experimental science with human participants rather than applied clinical development.Apply for PAR 21 039
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.313, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.853, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2020-11-09.
- Applicants must submit their applications by 2023-12-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| NIH Blueprint for Neuroscience Research: Tools and Technologies to Explore Nervous System Biomolecular Condensates (R21 Clinical Trial Not Allowed) Apply for RFA DA 22 008 Funding Number: RFA DA 22 008 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $200,000 |
| Building Interdisciplinary Research Careers in Women's Health Program (BIRCWH) (K12 Clinical Trial Optional) Apply for RFA OD 21 006 Funding Number: RFA OD 21 006 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $600,000 |
| NIH Blueprint and BRAIN Initiative Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award (F99/K00 Clinical Trial Not Allowed) Apply for RFA NS 21 012 Funding Number: RFA NS 21 012 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 21 261 Funding Number: PA 21 261 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional) Apply for PAR 21 303 Funding Number: PAR 21 303 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Blueprint for Neuroscience Research Short Courses in Neurotherapeutics Development (R25 Clinical Trial Not Allowed) Apply for RFA NS 21 025 Funding Number: RFA NS 21 025 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $250,000 |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) Apply for PAR 22 060 Funding Number: PAR 22 060 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $375,000 |
| Implementation Research to Reduce Noncommunicable Disease (NCD) Burden in Low- and Middle-Income Countries (LMICs) and Tribal Nations During Critical Life Stages and Key Transition Periods (R01 Clinical Trial Optional) Apply for PAR 22 132 Funding Number: PAR 22 132 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed) Apply for PAR 22 160 Funding Number: PAR 22 160 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed) Apply for PAR 22 106 Funding Number: PAR 22 106 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) Apply for PAR 22 109 Funding Number: PAR 22 109 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $275,000 |
| PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 22 179 Funding Number: PA 22 179 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $275,766 |
| Research Coordinating Center to Support Climate Change and Health Community of Practice (U24 Clinical Trial Not Allowed) Apply for RFA ES 22 003 Funding Number: RFA ES 22 003 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $225,000,000 |
| NIH Blueprint for Neuroscience Research: Computational Training in Neuroscience and Behavior (T90/R90 - Clinical Trial Not Allowed) Apply for RFA DA 23 037 Funding Number: RFA DA 23 037 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $500,000 |
| Exploratory Grants for Climate Change and Health Research Center Development (P20 Clinical Trial Optional) Apply for RFA ES 23 007 Funding Number: RFA ES 23 007 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $850,000 |
| Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program in the Neurosciences (T32 Clinical Trial Not Allowed) Apply for PAR 22 265 Funding Number: PAR 22 265 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Blueprint for Neuroscience Research: Tools and Technologies to Explore Nervous System Biomolecular Condensates (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 039 Funding Number: RFA DA 24 039 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Single Source : NIH Blueprint for Neuroscience Research: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed) Apply for RFA EB 23 003 Funding Number: RFA EB 23 003 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $700,000 |
| PHS 2023-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 23 233 Funding Number: PA 23 233 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Single Source: NIH Blueprint for Neuroscience Research: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed) Apply for RFA EB 23 007 Funding Number: RFA EB 23 007 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $700,000 |
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