Opportunity Information: Apply for RFA AA 21 005

The Specialized Alcohol Research Centers (P50 Clinical Trial Optional) funding opportunity (RFA AA 21 005) is a discretionary grant program from the U.S. Department of Health and Human Services through the National Institutes of Health, specifically the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The purpose of this opportunity is to support a broad-based Alcohol Research Centers program designed to strengthen and accelerate interdisciplinary, collaborative research focused on alcoholism and alcohol use disorder, as well as the many ways alcohol affects health and contributes to disease. In practice, this kind of center-based mechanism is intended to bring multiple investigators, disciplines, and research components together under a unified structure so the whole center can tackle complex alcohol-related problems more effectively than isolated projects could on their own.

The program uses the P50 Specialized Center grant mechanism and is labeled “Clinical Trial Optional,” meaning applicants may propose clinical trials if they are appropriate to the center’s goals, but clinical trials are not required. The activity category is Health, and the assistance listing (CFDA) number tied to the program is 93.273, which corresponds to NIAAA’s research support. NIAAA’s emphasis in this announcement is on fostering collaboration and integration across research areas, encouraging teams to study alcohol-related conditions and outcomes in a coordinated way that can span basic, translational, clinical, and population-focused work, depending on the center’s scientific vision.

Eligibility is broad and includes many types of U.S.-based organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and additional applicant types as allowed under the full eligibility language referenced in the opportunity. This wide eligibility is meant to accommodate the varied institutional settings where alcohol research and community-facing health research may take place, including academic medical centers, research institutes, healthcare-linked nonprofits, and certain private-sector research entities.

In terms of funding scale and competition, the opportunity lists an award ceiling of $1,150,000 and anticipated funding for a very limited number of awards, with an expected number of awards equal to 1. The announcement was created on April 5, 2021, with an original closing date of November 15, 2021. Because center grants typically support coordinated, multi-component research programs, the funding level and single expected award suggest a highly competitive process focused on selecting one especially strong, well-integrated center proposal aligned with NIAAA priorities.

Overall, this opportunity is best understood as support for an organized research “hub” that can sustain a coherent theme around alcohol misuse, alcohol use disorder, and alcohol’s broader health impacts, while leveraging collaboration to produce findings that are more comprehensive, efficient, and translatable. The intent is not just to fund individual studies, but to enable a structured research center environment where shared expertise, coordinated projects, and potentially shared resources can drive progress on major alcohol-related public health and biomedical challenges.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Specialized Alcohol Research Centers (P50 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
  • This funding opportunity was created on Apr 05, 2021.
  • Applicants must submit their applications by Nov 15, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,150,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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