Opportunity Information: Apply for RFA DK 19 019
The Food as Medicine: Food Insecurity and HIV-related Comorbidities, Coinfections, and Complications within the Mission of the NIDDK (R01 Clinical Trial Optional) funding opportunity (RFA-DK-19-019) is a National Institutes of Health (NIH) discretionary grant program that supports U.S.-based research focused on the relationship between food insecurity and HIV-associated health outcomes that fall within the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) mission areas. The central idea is to fund studies that clarify how limited or uncertain access to adequate food can contribute to the development, worsening, or persistence of HIV-related comorbidities, coinfections, and complications (often abbreviated as CCCs), particularly when those CCCs overlap with NIDDK priorities such as diabetes, digestive diseases, nutrition-related conditions, and kidney or metabolic complications.
Projects proposed under this announcement are expected to do more than simply document that food insecurity and poor outcomes co-occur. The FOA emphasizes understanding pathways and mechanisms. Applicants can propose research that examines the biological, nutritional, behavioral, and healthcare-related routes through which food insecurity may drive CCC risk, progression, or severity. For example, a project might investigate how nutritional inadequacy (insufficient calories, protein, or micronutrients; poor diet quality; irregular meal patterns) interacts with HIV treatment and metabolism to increase risk for diabetes or kidney disease, or how food insecurity shapes medication adherence, clinic attendance, stress physiology, and other health-related behaviors that indirectly influence HIV-related complications. The announcement also welcomes work that tests or evaluates interventions aimed at alleviating food insecurity and then assesses how those interventions lead to improvements in CCCs, with particular attention to the underlying mechanisms of improvement rather than only top-line outcomes.
The mechanism of support is an R01 research project grant, and clinical trials are optional, meaning applicants may propose either observational/mechanistic studies or interventional studies that meet the NIH definition of a clinical trial, as long as the work aligns with the FOA focus. The activity category is listed under Food and Nutrition and Health, and the program is associated with CFDA number 93.847. The award ceiling is noted as $500,000, indicating a maximum funding level per award (typically understood as a direct cost cap unless otherwise specified in the full announcement). The FOA record lists an original closing date of March 9, 2020, and a creation date of August 30, 2019, which situates the opportunity in that funding cycle.
Eligibility is broad but anchored in U.S. domestic applications. Eligible applicants include many types of government entities (state, county, city or township, and special district governments), federally recognized Native American tribal governments, public and state-controlled institutions of higher education, private institutions of higher education, independent school districts, public housing authorities/Indian housing authorities, and a wide range of nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified). For-profit organizations other than small businesses and small businesses are also eligible. The FOA explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it clearly restricts non-U.S. organizations: non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant organization can include certain foreign elements of the project when justified and compliant with NIH policy, even though the applicant institution itself must be domestic.
In practical terms, this FOA is aimed at strengthening evidence on food insecurity as a modifiable social and nutritional determinant of health in people with HIV, with a specific spotlight on complications and comorbid conditions that match NIDDK priorities. Competitive applications would typically be expected to articulate clear hypotheses about mechanisms (nutritional, metabolic, behavioral, or healthcare access-related), define CCC outcomes with strong measurement plans, and, when proposing interventions, explain how reducing food insecurity is anticipated to translate into measurable improvements in HIV-related complications through identifiable causal pathways.Apply for RFA DK 19 019
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Food as Medicine: Food Insecurity and HIV-related Comorbidities, Coinfections, and Complications within the Mission of the NIDDK (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2019-08-30.
- Applicants must submit their applications by 2020-03-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Food as Medicine: Food Insecurity and HIV-related Comorbidities, Coinfections, and Complications within the Mission of the NIDDK (R01 Clinical Trial Optional) (RFA-DK-19-019)
What is this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity that supports U.S.-based research on how food insecurity relates to HIV-associated health outcomes, specifically HIV-related comorbidities, coinfections, and complications (CCCs) that fall within the mission areas of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the goal of the FOA?
The goal is to fund studies that clarify how limited or uncertain access to adequate food can contribute to the development, worsening, or persistence of HIV-related CCCs, especially when those CCCs overlap with NIDDK priority areas such as diabetes, digestive diseases, nutrition-related conditions, and kidney or metabolic complications.
What types of research does the FOA emphasize?
The FOA emphasizes pathway- and mechanism-focused research. Projects are expected to go beyond documenting that food insecurity and poor outcomes co-occur, and instead investigate how and why food insecurity may drive CCC risk, progression, or severity through biological, nutritional, behavioral, and healthcare-related routes.
What does "food insecurity" mean in the context of this announcement?
In this context, food insecurity refers to limited or uncertain access to adequate food, including situations involving nutritional inadequacy such as insufficient calories, protein, or micronutrients; poor diet quality; and irregular meal patterns.
What are "HIV-related comorbidities, coinfections, and complications (CCCs)"?
CCCs is a shorthand used in the announcement for HIV-related comorbidities, coinfections, and complications. The FOA particularly focuses on CCCs that overlap with NIDDK mission areas (for example, diabetes risk, kidney disease, metabolic complications, digestive diseases, and other nutrition-related conditions).
What kinds of mechanisms or pathways can applicants study?
The announcement highlights several categories of mechanisms, including biological, nutritional, behavioral, and healthcare-related pathways. Example topics mentioned include how nutritional inadequacy interacts with HIV treatment and metabolism to increase risk for diabetes or kidney disease, and how food insecurity may influence medication adherence, clinic attendance, stress physiology, and other health-related behaviors that indirectly affect HIV-related complications.
Are intervention studies allowed, or is this only observational research?
Both are allowed. Applicants may propose observational/mechanistic studies or interventions that alleviate food insecurity and then assess how those changes lead to improvements in CCCs. The FOA places special emphasis on explaining and measuring the underlying mechanisms of improvement, not only overall outcome changes.
Are clinical trials allowed under this FOA?
Yes. The funding opportunity uses an R01 mechanism with "Clinical Trial Optional" status. That means clinical trials may be proposed if they meet the NIH definition of a clinical trial and align with the FOA focus, but a clinical trial is not required.
What grant mechanism is being used?
The mechanism of support is an R01 research project grant.
What is the award ceiling?
The award ceiling is listed as $500,000, indicating a maximum funding level per award (typically understood as a direct cost cap unless otherwise specified in the full announcement).
What NIH institute is associated with this FOA?
The FOA is within the mission scope of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and focuses on HIV-related CCCs that overlap with NIDDK priority areas.
What program category is this opportunity associated with?
The activity category is listed under Food and Nutrition and Health.
What is the CFDA number listed for this opportunity?
The opportunity is associated with CFDA number 93.847.
Who is eligible to apply?
Eligibility is broad but limited to U.S. domestic applicants. Eligible applicants include state, county, city or township, and special district governments; federally recognized Native American tribal governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified); for-profit organizations other than small businesses; and small businesses.
Does the FOA name specific institution types as eligible?
Yes. It explicitly highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
Are non-U.S. organizations eligible to apply?
No. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed at all?
Yes. While the applicant organization must be domestic, the FOA allows foreign components as defined in the NIH Grants Policy Statement, meaning a U.S. applicant can include certain foreign elements of the project when justified and compliant with NIH policy.
What kinds of projects would be considered non-responsive based on the FOA emphasis?
Projects that only document that food insecurity and poor outcomes occur together, without addressing pathways or mechanisms, would not align with the FOA emphasis. The announcement expects studies to articulate how food insecurity contributes to CCC risk, progression, or severity, and to include clear measurement and hypothesis-driven plans around those mechanisms.
What does the FOA suggest for competitive intervention proposals?
When proposing interventions aimed at alleviating food insecurity, competitive proposals would typically explain how reducing food insecurity is anticipated to translate into measurable improvements in HIV-related CCCs through identifiable causal pathways, and include plans to evaluate those mechanisms (not only top-line outcomes).
What are key elements the FOA implies for strong applications?
Based on the description, strong applications would typically include clear, mechanism-focused hypotheses (nutritional, metabolic, behavioral, and/or healthcare access-related), well-defined CCC outcomes with solid measurement plans, and (if applicable) a rationale for how interventions that reduce food insecurity produce improvements in HIV-related CCCs through measurable pathways.
What is the FOA number and title?
The FOA is RFA-DK-19-019, titled "The Food as Medicine: Food Insecurity and HIV-related Comorbidities, Coinfections, and Complications within the Mission of the NIDDK (R01 Clinical Trial Optional)."
When was this opportunity created and when did it close?
The FOA record lists a creation date of August 30, 2019, and an original closing date of March 9, 2020.
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