Opportunity Information: Apply for RFA DK 25 010
The Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional) funding opportunity (RFA-DK-25-010) is a National Institutes of Health (NIH) center grant run through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports the creation or continuation of Cystic Fibrosis (CF) Research and Translation Core Centers, which are meant to strengthen both basic science and clinical research efforts in CF by building shared infrastructure, coordinated services, and a collaborative research environment. The overall aim is to accelerate the development and testing of new therapies for CF by supporting institutions that already have a strong, proven base of CF research excellence and that can leverage centralized cores to improve efficiency, quality, and cross-project synergy.
The center structure emphasized in the announcement includes three main components. First, Research Core services provide shared resources that multiple investigators can use, such as specialized assays, models, biobanking, clinical research support, data management, or other enabling capabilities that would be inefficient for individual labs to maintain alone. Second, a Pilot and Feasibility (P&F) program is required to spark new ideas, bring new investigators into the CF field, or allow established teams to generate early data needed for larger independent grants; these pilots are typically used to seed innovative, higher-risk projects that could quickly translate into competitive external funding. Third, an Administrative Core is expected to coordinate the center as an integrated program, and it includes an enrichment program meant to build community and momentum through activities like seminar series, workshops, visiting speakers, training opportunities, or other events that promote collaboration and dissemination of CF research advances.
A major theme of this NOFO is collaboration and shared impact. These centers are not just collections of unrelated projects; they are intended to function as hubs that connect investigators, harmonize methods, and make high-value resources broadly available within a strong CF research ecosystem. NIDDK notes it already supports seven CF Research and Translation Centers at institutions with documented excellence in both basic and clinical CF research, and it provides links to information about the currently funded centers to help applicants understand the program landscape and expectations.
On eligibility, the opportunity is broadly open across many U.S.-based organization types, including state and local governments, public and private institutions of higher education, federally recognized tribal governments, certain tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others. The NOFO also explicitly mentions categories such as HBCUs, Hispanic-serving institutions, Tribal Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, faith-based or community-based organizations, and U.S. territories or possessions as eligible. At the same time, it draws a firm line on foreign involvement: non-U.S. (foreign) organizations cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed under this announcement.
From a funding details standpoint, it is a discretionary grant program under the health-related activity category (CFDA 93.847), and the listed award ceiling is $750,000. The original closing date shown is July 17, 2024, and the opportunity was created April 23, 2024. The “clinical trial optional” designation indicates that clinical trials may be included if appropriate, but they are not required; the center can focus on infrastructure and translational support that spans preclinical work, clinical research, or both, as long as the proposed cores and activities clearly strengthen CF research and translation capacity.
In practical terms, a competitive application would be expected to show a substantial existing CF research base; a coherent plan for shared cores that will be heavily used and clearly add value; a well-justified pilot program that will produce meaningful, fundable next-step results; and an administrative/enrichment plan that demonstrably increases collaboration, rigor, and productivity across the CF research community at the institution (and potentially across partnering institutions).Apply for RFA DK 25 010
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2024-04-23.
- Applicants must submit their applications by 2024-07-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional) - RFA-DK-25-010
What is this funding opportunity?
This opportunity funds Cystic Fibrosis (CF) Research and Translation Core Centers under the NIH P30 center grant mechanism. The goal is to create or continue centers that strengthen CF basic science and clinical research by providing shared infrastructure, coordinated services, and a collaborative research environment.
Which agency is offering this grant?
The funding opportunity is run by the National Institutes of Health (NIH) through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the NOFO or solicitation number?
The solicitation is RFA-DK-25-010, titled "Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional)."
What is the main purpose of these centers?
The centers are intended to accelerate the development and testing of new therapies for cystic fibrosis by strengthening institutional CF research capacity. They do this by centralizing high-value resources (cores), coordinating activities across investigators, and promoting cross-project synergy.
What kinds of institutions are these centers meant for?
The announcement emphasizes support for institutions that already have a strong, proven base of CF research excellence and can leverage centralized cores to improve efficiency, quality, and collaboration across multiple CF projects and investigators.
What are the required major components of the center?
The NOFO emphasizes three main components: (1) Research Core services, (2) a required Pilot and Feasibility (P&F) program, and (3) an Administrative Core that includes an enrichment program.
What are Research Cores in this program?
Research Cores are shared resources and services designed for use by multiple investigators. Examples mentioned include specialized assays, models, biobanking, clinical research support, data management, and other enabling capabilities that are inefficient for individual labs to maintain independently.
Is a Pilot and Feasibility (P&F) program required?
Yes. The Pilot and Feasibility program is required and is intended to spark new ideas, attract new investigators into CF research, and help teams generate early data needed to pursue larger independent grants.
What is the purpose of the Pilot and Feasibility (P&F) program?
The P&F program is meant to seed innovative and potentially higher-risk projects that can quickly translate into competitive external funding. It can be used to support new investigators, bring established investigators into the CF field, or help established CF teams gather preliminary data for next-step applications.
What does the Administrative Core do?
The Administrative Core is expected to coordinate the center as an integrated program. It also includes an enrichment program aimed at building community, sustaining momentum, and improving collaboration across CF research activities.
What is the enrichment program and what activities might it include?
The enrichment program is part of the Administrative Core and may include activities like seminar series, workshops, visiting speakers, training opportunities, and other events that promote collaboration and dissemination of CF research advances.
Are these centers expected to be collaborative rather than a set of unrelated projects?
Yes. A major theme is collaboration and shared impact. The centers are intended to function as hubs that connect investigators, harmonize methods, and make high-value resources broadly available within a strong CF research ecosystem.
What does "Clinical Trial Optional" mean in this NOFO?
"Clinical trial optional" means clinical trials may be included if appropriate, but they are not required. A center may focus on infrastructure and translational support spanning preclinical work, clinical research, or both, as long as the proposed cores and activities clearly strengthen CF research and translation capacity.
What is the award ceiling for this opportunity?
The listed award ceiling is $750,000.
What is the CFDA number and activity category?
The opportunity is listed under CFDA 93.847 and is categorized as a health-related activity.
What type of grant program is this?
This is a discretionary grant program under an NIH center grant mechanism (P30).
What is the original closing date shown for this opportunity?
The original closing date shown is July 17, 2024.
When was this opportunity created?
The opportunity was created on April 23, 2024.
Who is eligible to apply?
Eligibility is broadly open across many U.S.-based organization types, including state and local governments, public and private institutions of higher education, federally recognized tribal governments, certain tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others.
Are minority-serving institutions and community-based organizations eligible?
Yes. The NOFO explicitly mentions categories such as HBCUs, Hispanic-serving institutions, Tribal Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, and faith-based or community-based organizations as eligible.
Are U.S. territories or possessions eligible?
Yes. The eligibility description explicitly includes U.S. territories or possessions.
Can foreign organizations apply?
No. Non-U.S. (foreign) organizations cannot apply under this announcement.
Are foreign components allowed as part of an application?
No. The NOFO states that non-U.S. components of U.S. organizations are not eligible and that foreign components (as defined by NIH policy) are not allowed.
How many CF Research and Translation Centers does NIDDK already support?
NIDDK notes that it already supports seven CF Research and Translation Centers at institutions with documented excellence in both basic and clinical CF research.
What does NIDDK expect to see in a competitive application?
Based on the description provided, competitive applications are expected to show: (1) a substantial existing CF research base, (2) a coherent plan for shared cores that will be heavily used and clearly add value, (3) a well-justified pilot program designed to produce meaningful next-step, fundable results, and (4) an administrative and enrichment plan that demonstrably increases collaboration, rigor, and productivity across the CF research community.
What kinds of benefits are these centers supposed to create?
The centers are designed to improve efficiency and quality by centralizing specialized resources, increase coordination and shared methods across investigators, and create a stronger collaborative environment that speeds CF research translation from basic findings toward clinical testing and therapy development.
Do these centers support only basic research or only clinical research?
The center can support basic science, clinical research, or a combination, as long as the overall design (cores, P&F program, and administration/enrichment) strengthens CF research and translation capacity and aligns with the program goals.
Browse more opportunities from the same category: Food and Nutrition, Health
Next opportunity: DRL Supporting Civic Oversight of the Security Sector in Ukraine
Previous opportunity: Research Facilities Act Program
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DK 25 010
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 25 010) also looked into and applied for these:
| Funding Opportunity |
|---|
| Coordinating Center for Type 1 Diabetes TrialNet (U01 Clinical Trial Required) Apply for RFA DK 25 004 Funding Number: RFA DK 25 004 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Type 1 Diabetes TrialNet Clinical Network Hub (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 005 Funding Number: RFA DK 25 005 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Nutrition Obesity Research Centers Research Resource Center (RRC) (P2C- Clinical Trial Optional) Apply for RFA DK 25 011 Funding Number: RFA DK 25 011 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $625,000 |
| Nutrition Obesity Research Centers (P30 Clinical Trial Optional) Apply for RFA DK 25 007 Funding Number: RFA DK 25 007 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 012 Funding Number: RFA DK 25 012 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $5,500,000 |
| Single Source for Chronic Pancreatitis Clinical Research Consortium (CPCRC) Data Coordinating Center (CPCRC-DCC) (U01 Clinical Trial Optional) Apply for RFA DK 25 020 Funding Number: RFA DK 25 020 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| The Chronic Pancreatitis Clinical Research Consortium (CPCRC)- Clinical Centers (CPCRC-CCs) (U01 Clinical Trial Optional) Apply for RFA DK 25 019 Funding Number: RFA DK 25 019 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 15 343 Funding Number: PAR 15 343 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Impact of the Use of Glucose Monitoring and Control Technologies on Health Outcomes and Quality of Life in Older Adults with Type 1 Diabetes (T1D) (DP3) Apply for RFA DK 15 028 Funding Number: RFA DK 15 028 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3) Apply for RFA DK 15 019 Funding Number: RFA DK 15 019 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional) Apply for RFA DK 25 024 Funding Number: RFA DK 25 024 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Central Coordinating Site for the Polycystic Kidney Disease Research Core Centers (U24 Clinical Trial Not Allowed) Apply for RFA DK 25 015 Funding Number: RFA DK 25 015 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Polycystic Kidney Disease Core Centers (U54 Clinical Trial Not Allowed) Apply for RFA DK 25 016 Funding Number: RFA DK 25 016 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Single Source for the Continuation of the Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional) Apply for RFA DK 25 018 Funding Number: RFA DK 25 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $800,000 |
| Limited Competition for the Continuation of Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers (T1DAPC-CCs) (U01 Clinical Trial Optional) Apply for RFA DK 25 017 Funding Number: RFA DK 25 017 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Research Resource for Human Organs and Tissues (U42 Clinical Trial Not Allowed) Apply for PAR 24 258 Funding Number: PAR 24 258 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Urology Centers Program Interactions Core (U24 Clinical Trial Not Allowed) Apply for RFA DK 26 002 Funding Number: RFA DK 26 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Cellular Models of HIV Pathogenesis within NIDDK Mission Areas (R01 Clinical Trial Not Allowed) Apply for RFA DK 25 021 Funding Number: RFA DK 25 021 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Precision Medicine for Type 1 Diabetic Nephropathy (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 022 Funding Number: RFA DK 25 022 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) Apply for PAS 25 205 Funding Number: PAS 25 205 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DK 25 010", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.