Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional) | RFA DK 25 010

Opportunity Information: Apply for RFA DK 25 010

The Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional) funding opportunity (RFA-DK-25-010) is a National Institutes of Health (NIH) center grant run through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports the creation or continuation of Cystic Fibrosis (CF) Research and Translation Core Centers, which are meant to strengthen both basic science and clinical research efforts in CF by building shared infrastructure, coordinated services, and a collaborative research environment. The overall aim is to accelerate the development and testing of new therapies for CF by supporting institutions that already have a strong, proven base of CF research excellence and that can leverage centralized cores to improve efficiency, quality, and cross-project synergy.

The center structure emphasized in the announcement includes three main components. First, Research Core services provide shared resources that multiple investigators can use, such as specialized assays, models, biobanking, clinical research support, data management, or other enabling capabilities that would be inefficient for individual labs to maintain alone. Second, a Pilot and Feasibility (P&F) program is required to spark new ideas, bring new investigators into the CF field, or allow established teams to generate early data needed for larger independent grants; these pilots are typically used to seed innovative, higher-risk projects that could quickly translate into competitive external funding. Third, an Administrative Core is expected to coordinate the center as an integrated program, and it includes an enrichment program meant to build community and momentum through activities like seminar series, workshops, visiting speakers, training opportunities, or other events that promote collaboration and dissemination of CF research advances.

A major theme of this NOFO is collaboration and shared impact. These centers are not just collections of unrelated projects; they are intended to function as hubs that connect investigators, harmonize methods, and make high-value resources broadly available within a strong CF research ecosystem. NIDDK notes it already supports seven CF Research and Translation Centers at institutions with documented excellence in both basic and clinical CF research, and it provides links to information about the currently funded centers to help applicants understand the program landscape and expectations.

On eligibility, the opportunity is broadly open across many U.S.-based organization types, including state and local governments, public and private institutions of higher education, federally recognized tribal governments, certain tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others. The NOFO also explicitly mentions categories such as HBCUs, Hispanic-serving institutions, Tribal Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, faith-based or community-based organizations, and U.S. territories or possessions as eligible. At the same time, it draws a firm line on foreign involvement: non-U.S. (foreign) organizations cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed under this announcement.

From a funding details standpoint, it is a discretionary grant program under the health-related activity category (CFDA 93.847), and the listed award ceiling is $750,000. The original closing date shown is July 17, 2024, and the opportunity was created April 23, 2024. The “clinical trial optional” designation indicates that clinical trials may be included if appropriate, but they are not required; the center can focus on infrastructure and translational support that spans preclinical work, clinical research, or both, as long as the proposed cores and activities clearly strengthen CF research and translation capacity.

In practical terms, a competitive application would be expected to show a substantial existing CF research base; a coherent plan for shared cores that will be heavily used and clearly add value; a well-justified pilot program that will produce meaningful, fundable next-step results; and an administrative/enrichment plan that demonstrably increases collaboration, rigor, and productivity across the CF research community at the institution (and potentially across partnering institutions).

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2024-04-23.
• Applicants must submit their applications by 2024-07-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $750,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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