Opportunity Information: Apply for RFA CA 23 026

The National Institutes of Health (NIH) funding opportunity "Advancing Cancer Control Equity Research Through Transformative Solutions" (RFA-CA-23-026) supports research programs aimed at reducing cancer inequities by focusing on how social determinants of health (SDOH) drive worse cancer outcomes in underserved communities. This opportunity uses a U19 cooperative agreement mechanism, meaning funded projects are expected to involve substantial NIH scientific and programmatic involvement in addition to the awardee-led work. The activity area is health, and clinical trials are optional under this announcement.

At its core, the program is designed to stimulate community-engaged, multilevel intervention research in cancer control. "Multilevel" here means applicants are expected to go beyond single-point solutions and instead address interconnected pathways that operate across levels such as individuals, families, health care systems, neighborhoods, and broader policy or structural environments. The goal is not only to test or implement interventions, but to do so in ways that directly respond to real-world conditions that shape cancer prevention, screening, diagnosis, treatment, survivorship, and mortality patterns.

The announcement lays out three main expectations for applicants. First, projects should develop interventions that explicitly target the pathways through which SDOH contribute to adverse cancer outcomes. This implies interventions should be theory-driven and designed to interrupt or change the mechanisms linking social and structural conditions (for example, access barriers, discrimination, transportation, housing instability, food insecurity, insurance gaps, or neighborhood-level resource deficits) to cancer-related disparities. Second, applicants are expected to develop or strengthen methods and measures to assess community-level SDOH as well as community engagement processes and cancer control equity outcomes. In practice, this emphasis signals that NIH is looking for strong measurement strategies, meaningful indicators of equity-related change, and rigorous approaches for evaluating both how community engagement is carried out and whether it improves intervention relevance, uptake, and impact. Third, the program aims to build capacity among diverse scholars, stakeholders, and community partners to implement interventions grounded in lived experience. That capacity-building focus suggests that competitive applications will demonstrate authentic partnership structures, shared decision-making, training or mentorship components, and plans to sustain equitable collaboration beyond the life of the grant.

Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The opportunity also explicitly highlights additional eligible applicant groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, foreign organizations and foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.

Key administrative details included in the source information are that the award instrument is a cooperative agreement, the Assistance Listing (CFDA) number is 93.396, and the original closing date was September 14, 2023. The listed award ceiling is $1,500,000, indicating the maximum funding level per award under the terms described in the posting. Overall, the opportunity is positioned for teams capable of combining rigorous cancer control research with deep community partnership, strong multilevel intervention design, and practical measurement approaches that can demonstrate progress toward equity in real settings.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advancing Cancer Control Equity Research Through Transformative Solutions (U19 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
  • This funding opportunity was created on 2023-06-28.
  • Applicants must submit their applications by 2023-09-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA CA 23 026

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